Protocin

Protocin

oxytocin

Manufacturer:

Meprofarm

Marketer:

Meprofarm
Concise Prescribing Info
Contents
Oxytocin
Indications/Uses
Induction of labor in cases of post-term gestation, premature membrane rupture, preeclampsia; labor stimulation in certain cases of uterine inertia. Adjunctive therapy in an incomplete & unavoidable miscarriage in the early stages of pregnancy. Caesarean section. Prevention & treatment of postpartum uterine atony & bleeding, uterine bleeding after childbirth.
Dosage/Direction for Use
IV infusion Labor induction or stimulation Initially 1-4 milliunit/min (2-8 drops/min), increase gradually at intervals not <20 min. In pregnancy closer to date, <10 milliunit/min (20 drops/min). Max speed: 20 milliunit/min (40 drops/min). Caesarean section 5 IU after delivery. Prevention of uterine bleeding after childbirth 5 IU by IV drops infusion w/ variety infusion rate for >5 min or 5-10 IU by IM inj after placental delivery. In women given oxytocin to stimulate labor, the infusion should be continued at a pace that improved during the 3rd stage of labor & for the next several hr. Treatment of uterine bleeding after childbirth 5 IU by IV drops infusion w/ variety infusion rate for >5 min or 5-10 IU by IM inj. More severe cases 5-20 IU of oxytocin in 500 mL of electrolyte soln. Incomplete, unavoidable miscarriage or abortion failure 5 IU by IV drops infusion w/ variety infusion rate for >5 min or 5-10 IU by IM inj, if necessary, can be followed by IV infusion at a rate of 20-40 milliunits or faster.
Contraindications
Hypersensitivity. Hypertonic uterine contractions, fetal distress at premature childbirth. In conditions in order to ensure safety to the fetus or the mother where normal childbirth is not recommended &/or vag delivery is contraindicated eg, disproportion cephalopelvic, abnormal fetal position, placenta previa, placenta abruption, umbilical cord position or prolapse, the strain of excessive or impairment of the uterine wall as in a twin pregnancy, polyhydramnions, frequent childbirth, scarred uterus due to major surgery including classical caesarean section.
Special Precautions
Prolonged use in patients w/ severe CV disorders. Do not give as a bolus IV inj. Can lead to short-term acute hypotension accompanied by "flushing" & tachycardia. CV impairment. Long QT syndrome. May affect ability to drive or use machines. Lactation.
Adverse Reactions
Headache; tachycradia, bradycardia; nausea.
Drug Interactions
Inhalation anesth eg, cyclopropane, halothane may stimulate hypotensive effect of oxytocin & can cause heart rate disturbances. Can amplify the effect of the pressure of sympathomimetic vasoconstrictor agents. Prostaglandins & analogs facilitate contraction in the myometrium. Oxytocin is potentially arrhythmogenic, especially in patients w/ other risk factors for "Torsades de pointes" eg, drugs that prolong QT interval or patients w/ long QT syndrome.
MIMS Class
Drugs Acting on the Uterus
ATC Classification
H01BB02 - oxytocin ; Belongs to the class of oxytocin and analogues. Used in posterior pituitary lobe hormone preparations.
Presentation/Packing
Form
Protocin inj 10 IU/mL
Packing/Price
10 × 1's (Rp72,000/boks)
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