Prostimix

Prostimix

propylthiouracil

Manufacturer:

Ifars
Concise Prescribing Info
Contents
Propylthiouracil
Indications/Uses
Symptomatic relief & surgical prep of hyperthyroidism. May be used in combination w/ radioactive iodine to accelerate clinical improvement while awaiting the therapeutic effects of radioactive iodine.
Dosage/Direction for Use
Adult Initially 300-600 mg daily in divided doses, w/ 6-8 hr interval. May increase to 1.2 g daily in initial control, administered until patients reach euthyroid condition. Maintenance dose: 100-300 mg in 3 divided doses. Thyrotoxic crisis 600-1,200 mg in divided doses. Childn >10 yr Initially 50-300 mg daily in divided doses, w/ 6-8 hr interval. Maintenance dose: 100-300 mg daily in 2 divided doses w/ 2 hr intervals, 6-10 yr Initially 50-150 mg daily in divided doses, w/ 6-8 hr interval. Neonatal thyrotoxicosis 10 mg/kg.
Contraindications
Hypersensitivity. Congenital abnormalities; hypothyroidism. Pregnancy (especially in 3rd trimester) & lactation.
Special Precautions
Hypersensitivity. Monitor patients for symptoms of agranulocytosis (eg, headache, fever, soar throat, skin damage, feeling unwell) & advise to contact a doctor immediately if symptoms appear. Bone marrow depression, impaired liver function in asthmatics. Discontinue use in case of polyserositis syndrome that resembles lupus erythematosus. Patients who have had success w/ antithyroid treatment are at risk of hyperthyroidism; regularly check patients every yr. May cause fetal goiter & hyperthyroidism when given to pregnant woman. Adjust dose when used during pregnancy & discontinue therapy in the 3rd trimester of pregnancy.
Drug Interactions
Increased effect of anticoagulants eg, coumarin & heparin. Potential amplified hyperthyroidism & goitrogenic effects w/ K iodide or lithium. Increased risk of hepatotoxicity w/ hepatotoxic drugs.
MIMS Class
Antithyroid Agents
ATC Classification
H03BA02 - propylthiouracil ; Belongs to the class of thiouracils. Used in the management of thyroid diseases.
Presentation/Packing
Form
Prostimix tab 100 mg
Packing/Price
5 × 10's
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