Specific reversal agent for dabigatran & in patients treated w/ Pradaxa (dabigatran etexilate) when rapid reversal of anticoagulant effects is required (emergency surgery/urgent procedures, life-threatening or uncontrolled bleeding).
IV Recommended dose: 5 g (2 x 2.5 g/50 mL) as 2 consecutive infusions over 5-10 min each or as bolus inj. Recurrent bleeding/2nd emergency surgery/urgent procedure w/ prolonged clotting time 2nd 5-g dose may be considered. Restarting antithrombotic therapy: Pradaxa may be reinitiated 24 hr after Praxbind; other antithrombotic therapy (eg, LMWH) may be started at any time.
View Praxbind overdosage for action to be taken in the event of an overdose.
Special Precautions
Hypersensitivity (anaphylactoid reaction). Discontinue treatment if anaphylactic reaction or other serious allergic reaction occurs. Hereditary fructose intolerance. Underlying disease predisposing to thromboembolic events, in patients on dabigatran therapy. Patients on a controlled Na diet. Pregnancy & lactation. Childn <18 yr.
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