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Co-administration pioglitazone with digoxin, warfarin, phenprocoumon and metformin has not relevant effect on either with the pharmacokinetics and pharmacodynamics pioglitazone.
Co-administration of sulfonylurea and pioglitazone does not appear to affect the pharmacokinetics of the sulfonylurea. No induction of the man inducible cytochrome P-450, 1A, 2C8/9 and 3A4.
Interaction with drugs metabolized by enzymes such as oral contraceptives, cyclosporin, calcium-channel blocker and HMG-CoA reductase inhibitors are not to be expected.
