Antacids may be given w/in ½ hr before or after Pepco administration if needed. Cimetidine, ciprofloxacin, digoxin, ketoconazole, norfloxacin, phenytoin, ranitidine, tetracycline & theophylline should be taken w/in 2 hr after administration. Patients w/ chronic kidney failure & dialysis patients. Pregnancy. Nursing mothers. Childn.