Symptomatic treatment of acute exacerbations of OA (short-term), RA (long-term) & ankylosing spondylitis.
Dosage/Direction for Use
TabOA 7.5 mg/day. If necessary, increase to 15 mg/day. RA 15 mg/day. May be reduced to 7.5 mg/day according to therapeutic response. Elderly 7.5 mg/day for long-term treatment. Patient w/ increased risk for adverse reactions Initially w/ 7.5 mg/day. Ankylosing spondylitis 15 mg/day. Dialysis patient w/ severe renal failure Max: 7.5 mg/day. Supp Rectal administration: 1 supp once daily.
Administration
May be taken with or without food: May be taken w/ meals if GI discomfort occurs.
Contraindications
Cross-sensitivity w/ acetosal & other NSAIDs; signs of asthma, nasal polyps, angioedema & urticaria; severe hepatic & nondialysed severe renal insufficiency; cerebrovascular bleeding; active peptic ulcer, GI bleeding or other bleeding disorders. Pregnancy & lactation.
Special Precautions
Anticoagulant therapy; discontinue use if increased serum transaminases, GI bleeding & mucocutaneous adverse events occur. Childn & adolescent <15 yr. Elderly w/ impaired renal, hepatic or cardiac function.
Adverse Reactions
Dyspepsia, nausea, vomiting, constipation, diarrhea, flatulence, esophagitis, GI ulcer & bleeding, colitis; anemia, leucopenia, thrombocytopenia; skin rash, pruritus, urticaria, stomatitis; onset of asthma attack in patients allergic to acetosal or other NSAIDs; dizziness, drowsiness, tinnitus, vertigo; flushes, edema, increased BP, palpitations; abnormal renal function parameters; elevated transaminases or bilirubin.
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