GERD as an alternative to oral therapy if not appropriate eg, patients w/ esophagitis &/or severe symptoms of reflux; healing of gastric ulcers associated w/ NSAID therapy. Short-term maintenance of haemostasis & prevention of rebleeding in patients following endoscopy for acute gastric bleeding or duodenal ulcers.
Alternative to oral therapy 20-40 mg once daily. Reflux esophagitis 40 mg once daily. Symptomatic treatment of GERD 20 mg once daily. Healing of NSAID-associated gastric ulcers 20 mg once daily. Maintenance of haemostasis & prevention of rebleeding of gastric & duodenal ulcers 80 mg as bolus infusion over 30 min followed by continuous IV infusion of 8 mg/hr over 3 days. Severe hepatic impairment Max: 20 mg daily.
Avoid concomitant use w/ clopidogrel. Patients at risk for developing osteoprosis or osteoporotic fractures. Exclude gastric malignancy before treatment. Concomitant use w/ drugs metabolized via CYP3A4 eg, cisapride. Regular surveillance in patients on long-term treatment (>1 yr). Pregnancy. Not to be used during breast-feeding.
A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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