Mupirocin is a topical antibacterial agent. Mupirocin is produced by fermentation using the organism Pseudomonas fluorescens. It is active against those organisms responsible for the majority of skin infections, e.g. Staphylococcus aureus, including Methicilin-resistant strains, other Staphylococci and Streptococci by inhibition of bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer RNA synthetase. Due to this mode of action, Mupirocin demonstrates no in vitro cross-resistance with other clinically available antibiotic. It is also active against certain gram-negative pathogen, such as Eschericia coli and Haemophilus influenzae.
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