Short-term symptomatic treatment of acute exacerbation of OA. Long-term symptomatic treatment of RA (chronic polyarthritis).
Dosage/Direction for Use
AdultOA 7.5 mg daily, may be increased to 15 mg daily. RA 15 mg daily, may be reduced to 7.5 mg daily. Patient w/ a high-risk of adverse effect Initially 7.5 mg daily. Patient w/ severe renal failure Doses should not exceed 7.5 mg daily. Max recommended dose: 15 mg daily.
Administration
Should be taken with food.
Contraindications
Active gastric ulcer. GI & cerebrovascular bleeding, other bleeding disorders. Severe liver & renal (w/o dialysis) insufficiency. Patients w/ asthma, nasal polyp, angioedema or urticaria induced by acetylsalicylic or other NSAIDs. Pregnancy & lactation. Childn & adolescent <15 yr.
Special Precautions
History of upper GI disorders, antihaemostatic treatment. Peptic ulcer or GI bleeding (discontinue). Patients w/ reduced blood flow into the kidney eg, dehydration, CHF, liver cirrhosis, nephrotic syndrome, renal disease, diuretic treatment. Doses should not be >7.5 mg daily in patients w/ advanced renal failure w/ haemodialysis. Increase of serum transaminase. Pregnancy & lactation. Debility, elderly.
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