Meproson

Methylprednisolone

Rheumatic disorders, ulcerative colitis. Tab: Bronchial asthma (where treatment w/ sympathomimetics or theophylline fails to achieve the desired result or bronchial hyperactivity), allergic rhinitis, urticaria, eczema or dermatitis, hemolytic anemia, idiopathic thrombocytopenia, myeloblastosis, lymphogranulomatosis, nephrotic syndrome, skin disease, SLE, dermatomyositis. Inj: Endocrine, collagen, dermatologic disorders, allergic states, acute & chronic allergic & inflammation w/ ophth involvement; regional enteritis; resp disorders, hematological diseases, malignancy; edematous states; neurological disorders; TB meningitis w/ subarachnoid block or impending block, trichinosis w/ neurologic & myocardial involvement.

Tab Initially 4-48 mg daily. IV 30 mg/kg for 30 min, may be repeated every 4-6 hr for 48 hr.

Should be taken with food.

Hypersensitivity. Systemic fungal infections. Tab: Hypersensitivity to other glucocorticoids. Inj: Live or live attenuated vaccines. Premature babies.

HTN. Prolonged use may cause posterior subcapsular cataract & nuclear cataract (especially in childn), or increased glaucoma. Active, latent or reactive TB. Corticosteroid effect may be enhanced in hypothyroidism & cirrhosis. Pregnancy & lactation. Tab: Heart disease. Prolonged use may cause activity of viral or fungal ocular infections. Perform ocular exam every 3 mth in prolonged use. Blood glucose level should be monitored. Smallpox or other vaccinations, especially in high dose are not recommended. Prolonged use may inhibit growth & development in childn. Inj: Patients w/ unusual stress. May enhance susceptibility for infection. May mask several signs of infection & trigger new infections during therapy. Patients w/ increased serum creatinine level or secondary infections. Prolonged use may cause exophthalmos. Patients w/ CV risk, CHF, Cushing's disease, ocular herpes simplex, nonspecific ulcerative colitis, diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer, kidney insufficiency, osteoporosis, or myasthenia gravis. High dose may cause pancreatitis in childn. Prolonged use in infants or childn.

HTN, cataract, glaucoma. Vertigo, malaise. Tab: Moon face, fat deposit, muscle weakness, osteoporosis, reduced glucose tolerance, DM, impaired sexual hormones secretion, peptic ulcer, reduce body resistance, delayed growth in childn, thrombosis, pancreatitis. Headache, seizures, increased intracranial tension with papilla edema. Electrolyte & body fluid disturbances. Dermatology & immunology disorders. Euphoria, psychological dependence, mood-swing depression, personality changes, insomnia, increased intracranial tension w/ papilledema in childn (pseudotumor cerebry), psychosis, aggravated schizophrenia. Leucocytosis, hypersensitivity reactions including anaphylaxis reactions, thromboembolism, nausea. Inj: Opportunistic infections, hypersensitivity, Cushingoid, hypopituitarism, steroid w/drawal syndrome, metabolism & nutrition disorders, psychiatric disorders, neurological disorders, central serous chorioretinopathy, exophthalmos; CHF, arrhythmia; hypotension; hiccup; GI disturbances, skin & subcutaneous tissue disorders, musculoskeletal & adjunctive disorders, breast & reproductive system disorders, healing disturbances, fatigue, inj site reaction, compression spinal fracture, tendon rupture.

Tab: May increase the effect of cardiac glycosides. May increase K excretion w/ diuretics. Glucocorticoid may reduce hypoglycemic effect of antidiabetics & coumarin derivatives. Convulsion has been reported in concomitant use w/ cyclosporine. Ketoconazole & troleandomycin may inhibit metabolism & reduce methylprednisolone clearance. Metabolism may be increased w/ liver enzyme inducers eg, rifampicin, rifabutin, carbamazepine, phenobarb, phenytoin, pyrimidine, aminogluthetimide. Salicylic clearance in kidney may be increased by corticosteroid & steroid which lead to salicylic intoxication. Salicylate & NSAID should be used w/ caution when combined w/ corticosteroid in hypoprothrombinemia. Inj: INH, rifampicin, oral anticoagulants, carbamazepine, phenobarb, phenytoin, anticholinergic (neuromuscular blockers), anticholinesterase, antidiabetics, antiemetic (aprepitant, fosaprepitant), antifungal (itraconazole, ketoconazole), antiviral (HIV-PIs), aminoglutethimide, Ca channel blockers (diltiazem), OC (ethinylestradiol/norethindrone), grapefruit juice, immunosuppressants (cyclophosphamide), macrolides (clarithromycin, erythromycin, troleandomycin), NSAIDs (high dose aspirin).

Corticosteroid Hormones

H02AB04 - methylprednisolone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.

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