Medrol Adverse Reactions

Note: The following are typical for all systemic corticosteroids. Their inclusion in this list does not necessarily indicate that the specific event has been observed with this particular formulation:
Fluid and Electrolyte Disturbances: Sodium retention; fluid retention; congestive heart failure in susceptible patients; potassium loss; hypokalemic alkalosis and hypertension.
Musculoskeletal: Muscle weakness; steroid myopathy; osteoporosis; aseptic necrosis and pathologic fractures.
Gastrointestinal: Peptic ulceration with possible perforation and hemorrhage; gastric hemorrhage; perforation of the bowel; pancreatitis; abdominal distention and ulcerative esophagitis.
Increases in alanine transaminase (ALT, SGPT), aspartate transaminase (AST, SGOT) and alkaline phosphatase have been observed following corticosteroid treatment. These changes are usually small, not associated with any clinical syndrome and are reversible upon discontinuation.
Dermatologic: Impaired wound healing; thin fragile skin; petechiae and ecchymosis; facial erythema; and increased sweating.
Neurological: Increased intracranial pressure, pseudotumor cerebri and seizures.
Endocrine: Development of Cushingoid state; suppression of pituitary-adrenal axis; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress as in trauma, surgery or illness; menstrual irregularities; decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; increased requirements for insulin or oral hypoglycemic agents in diabetics; suppression of growth in children.
Ophthalmic: Posterior subcapsular cataracts; increased intraocular pressure; glaucoma; and exophthalmos.
Metabolic: Negative nitrogen balance due to protein catabolism. The following additional reactions have been reported following oral as well as parenteral therapy: Urticaria and other allergic reactions, anaphylactic or hypersensitivity reactions.
Immune System: Masking of infections; latent infections becoming active; opportunistic infections; hypersensitivity reactions including anaphylaxis may suppress reactions to skin tests.