May increase GI effects if taken w/ high fat diet (2,000 cal daily or ≥30% total daily cal from fat). May reduce absorption of fat-soluble vit (A, D, E, K). Hepatic &/or renal disorders. Pregnancy & lactation. Childn <18 yr. Elderly.
Increased bioavailability & lipid lowering effect of pravastatin. Reduced absorption of vit D, E, β-carotene. Concomitant use w/ fibrate, acarbose, biguanide or anorectic drugs.
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