Lorlak Dosage/Direction for Use

The recommended dose schedule of Lorlak is 100 mg taken orally once daily continuously. Continue treatment as long as the patient is deriving clinical benefit from therapy. Lorlak may be taken with or without food. Patients should be encouraged to take their dose of lorlatinib at approximately the same time each day. Tablets should be swallowed whole (tablets should not be chewed, crushed or split prior to swallowing). No tablet should be ingested if it is broken, cracked, or otherwise not intact. If a dose of lorlatinib is missed, then it should be taken as soon as the patient remembers unless it is less than 4 hours before the next dose, in which case the patient should not take the missed dose. Patients should not take 2 doses at the same time to make up for a missed dose. Dose Modification: First dose reduction: Lorlak 75 mg taken orally once daily. Second dose reduction: Lorlak 50 mg taken orally once daily. Lorlak should be permanently discontinued if the patient is unable to tolerate Lorlak 50 mg taken orally once daily.