Avoid rapid IV inj. Patients w/ diabetes, recurrent renal calculi, under stool occult blood test or low Na diet or receiving anticoagulants should not use excessive & prolonged dose. May cause false result in urine glucose test. May cause false -ve result if consumed w/ in 48-72 hr prior to amine-dependent stool occult blood test. Large dose may increase oxalate acid level in urine & K oxalate precipitation in the kidney. Impaired kidney function &/or patients w/ a history of kidney stone. May cause hemolysis in patients w/ G6PD deficiency. May increase Fe absorption. Large dose can be dangerous for patients w/ hemochromatosis, thalassemia, polyerythema, leukemia, or sideroblastic anemia, sickle cell crisis. Pregnancy, lactation.
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