Increased levels of oxalic acid in the urine & possible deposition of Ca oxalate in the kidneys & a sickle cell crisis in large doses. Patients w/ G6PD deficiency, hemochromatosis, thalassemia, polycythemia, leukemia or sideroblastic anemia. Pain & thrombophlebitis (rare). Impaired kidney function &/or patients w/ history of kidney stones.