Hypersensitivity to aspirin or other NSAIDs; active peptic ulcer; known or suspected cerebrovascular bleeding; diathesis haemorrhage including coagulation disorders; partial or complete nasal polyps syndrome, angioedema or bronchospasm. Concomitant use w/ oxypentifylline, probenecid, lithium salts; hypovolemia; moderate to severe kidney disorders (CrCl >160 micromol/L); history of asthma, SJS or vesiculobullous rash; post-op patients w/ high-risk of haemorrhage or incomplete haemostasis, patients receiving low dose of heparin (2,500-5,000 U 12 hrly); neuraxial (epidural or intrathecal) administration. Not recommended as prophylaxis therapy for pre- & intra-op. Pregnancy & lactation. Childn <16 yr.