ER Cap: Control grand mal & psychomotor seizures (lobus temporalis epilepsy). Inj: Control grand mal status epilepticus & prevent seizures during neurosurgery.
Dosage/Direction for Use
EpilepsyER CapAdult Initially 100 mg 3 times daily. Maintenance: 300-400 mg daily, increase to 600 mg if necessary. Childn 5 mg/kg daily in 2-3 divided doses. Maintenance: 4-8 mg/kg daily. Max: 300 mg daily. InjAdult Loading dose: 10-15 mg/kg slow IV for not >50 mg/min. Maintenance dose: 100 mg orally or IV every 6-8 hr. Infant & childn Loading dose: 10-20 mg/kg IV for not >1-3 mg/min. Prevention of seizures during neurosurgery 100-200 mg (1-2 mL) IM w/ 4 hr interval during surgery & continued during the post-op period.
Special Precautions
Avoid abrupt w/drawal. Diabetes, hypotension, serious cardiac insufficiency. May impair ability to drive or operate machinery. Hepatic impairment. Pregnancy & lactation. Elderly or debilitated patients.
Some antibiotics, other anticonvulsants, cimetidine, coumarin anticoagulants, disulfiram, INH, some phenothiazines, phenylbutazone, sulfinpyrazone, carbamazepine. Avoid use w/ alcohol.
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