HTN, angina pectoris & stable chronic heart failure w/ declining left ventricular function. Adjunctive to ACE inhibitors, diuretics & cardiac glycosides if necessary.
Dosage/Direction for Use
HTN or angina pectoris 1 tab once daily, may be increased to 2 tab daily. Max: 4 tab daily. Stable chronic heart failure Initially 1.25 mg daily in 1st wk then titrate dose to 2.5, 3.75-5 mg daily every wk. Continue to titrate dose to 7.5-10 mg daily every mth. Maintenance dose: Based on patient's tolerability.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Acute heart failure or during episodes of heart failure decompensation requiring IV inotropic therapy, cardiogenic shock, 2nd or 3rd degree AV block, sick sinus syndrome, SA block, symptomatic bradycardia & hypotension, severe bronchial asthma, late stages of peripheral arterial occlusive disease or Raynaud's syndrome, untreated phaeochromocytoma, metabolic acidosis.
Bradycardia, dizziness, headache, GI problems eg, nausea, vomiting, diarrhea, constipation. Feeling of coldness or numbness in the extremities; asthenia, fatigue.
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