Jardiance Dosage/Direction for Use

Recommended dose and dosage adjustment: The recommended starting dose of JARDIANCE is 10 mg once daily. In patients tolerating empagliflozin 10 mg once daily who have an eGFR ≥60 ml/min/1.73m² and requiring additional glycemic control, the dose can be increased to 25 mg once daily. JARDIANCE can be taken with or without food. The maximum daily dose is 25 mg.
Patients with renal impairment: The efficacy of JARDIANCE is dependent on renal function. Renal function must be assessed prior to initiation of JARDIANCE therapy and periodically thereafter. No dosage adjustment for JARDIANCE is indicated in patients with mild renal impairment (eGFR ≥ 60mL/min/1.73m²).
JARDIANCE should not be initiated in patients with an eGFR <60mL/min/1.73m². JARDIANCE should be discontinued if eGFR falls below 45mL/min/1.73m². In patients with moderate impairment and eGFR ≥45mL/min/1.73m², close monitoring of renal function is recommended.
JARDIANCE should not be used in patients with end stage renal disease (ESRD) or in patients on dialysis as it is not expected to be effective in these patients.
Patients with hepatic insufficiency: No dosage adjustment for JARDIANCE is necessary for patients with mild or moderate hepatic impairment. JARDIANCE exposure is increased in patients with severe hepatic impairment. Experience in patients with severe hepatic impairment is limited. Therefore, JARDIANCE is not recommended for use in this population.
Elderly patients (>65 years of age): No dose adjustment for JARDIANCE is required based on age; however renal function and risk of volume depletion should be taken into account. Initiation of JARDIANCE therapy is not recommenced in patients aged ≥85 years as therapeutic experience is limited in this population.
Concomitant Use with sulfonylurea: When JARDIANCE is used as add-on therapy with a sulfonylurea, a lower dose of the sulfonylurea may be considered to reduce the risk of hypoglycemia.
Missed Dose: If a dose is missed, it should be taken as soon as the patient remembers. A double dose of JARDIANCE should not be taken on the same day.
Pediatrics (<18 years of age): The safety and efficacy of JARDIANCE in children under 18 years of age have not been established. Therefore, JARDIANCE should not be used in this population.