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Isivas may be administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma. In drug-interactions studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinatics of the following drugs: theophylline, prednisone, prednisolone, oral contraceptives (ethynil estradiol/norethindrone 35/1), terfenadine, digoxin and warfarin.
There are area under the plasma concentration-time curve (AUC) for montelukast was decreased approximately 40% in subjects with co-administration of Phenobarbital. No dosage adjustment for Isivas is recommended.
