Total: 250-300 mg/kg/course. Usual schedule: 50-60 mg/kg IV daily for 5 consecutive days.
Contraindications
Severe bone marrow depression; impaired renal function; bilateral urinary obstruction, acute infections, acute hemorrhagic cystitis. Pregnancy.
Special Precautions
Patients of reproductive age should use contraceptives during therapy & for the following 6 mth. Unilateral nephrectomies; brain metastases, infection, electrolyte imbalance.
Adverse Reactions
GI upsets; alopecia; reduction in blood count; cystitis; reversible encephalopathy. Immunosuppression. Occasionally, renal, hepatic & cardiac dysfunction in rare cases. Risk of secondary malignancies.
Neurotoxicity, hematotoxicity & nephrotoxicity may be increased by prior cisplatin therapy. Increased hypoglycemic effects w/ sulfonylureas. Increased bone marrow depression w/ allopurinol. Disturbances of anticoagulant control of warfarin.
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