Hishiphagen Special Precautions

Careful administration (HISHIPHAGEN should be administered with care in the following patients): Elderly patients [increased rate of hypokalemia] (see Use in Elderly as follows).
Important precautions: Thoroughly conduct interviews to predict occurrence of shocks.
Be prepared to provide emergency treatments in case shock occurs.
Maintain patient at rest after administration and carefully monitor the patient. HISHIPHAGEN should be administered with care when coadministered with products containing licorice because the overlap of glycyrrhizic acid contained in HISHIPHAGEN may cause pseudoaldosteronism.
Precautions concerning use: Rate of administration: Intravenous injections should be injected as slowly as possible while monitoring the patient.
Other precautions: Rhabdomyolysis has been reported in oral administration of products containing glycyrrhizic acid or licorice.
Use in Pregnancy & Lactation: HISHIPHAGEN should be used in patients that are pregnant or possibly pregnant only if the expected therapeutic benefits outweigh the possible risks. [Kidney malformation, etc., has been observed at massive doses of monoammonium glycyrrhizinate in animal studies (rats).]
Use in Elderly: HISHIPHAGEN should be used with caution while monitoring the patient. [In clinical experience, increased frequency of adverse reactions such as hypokalemia has been observed in elderly patients.]