Heparinol Dosage/Direction for Use

Express dose in units only; dose must be individually titrated to desired effect (usually 1.5 - 2 .5 times control clotting test used).
1. Treatment of venous thrombosis or pulmonary embolus. Duration of therapy is 7 -10 days, then followed by oral anticoagulation.
i) Continuous IV solution: 50-100 units/kg initially: then 10-15 units/kg/hr (venous thrombosis) or 20 units/kg/hr (pulmonary embolus).
ii) Intermittent IV: 75-125 units/kg q 4 hr.
iii) Subcutaneous: 10,000-20,000 units initially (proceeded by a 5000 units IV loading dose), then 8000-10,000 units q 8 hr or 15,000-20,000 units q 12 hr.
2. SC for prophylaxis of deep vein thrombosis (low- dose) 5000 units 2 hr before surgery, repeated q 8-12 hr until patient is ambulatory.
3. IV for heparin lock flush inject sufficient solution (of 10-100 units/ml) into injection hub to fill the entire after each heparin lock use.
4 . Haemodialysis: 7500-12,500 IU (without preservative) is normally required per dialysis.
5 . Myocardial infarction: 5 ,000 IU s.c. every 12 hours beginning during the 12 hours following the first sign of myocardial infarction.
6. Intravenous administration: 5000-10,000 IU every 4 hours either by bolus injection or continuous infusion in Sodium Chloride injection or dextrose injection. However, the dose should be monitored with coagulation tests performed just before each administration and varies according to individual response. The clotting time should be 2-3 times the control value.
7. Subcutaneous administration (therapeutic dose): Subcutaneous administration of 10,000 IU may be given every 8 hours after the initial intravenous bolus injection of 5000 IU.
8. Low dosage heparin regimen: The usual recommended dose is 5000 IU by subcutaneous injection every 8 or 12 hours without laboratory control. This regimen administration to: all Hemostatically competent patients over the age 40 subjected to major elective abdominal or thoracic surgical procedure.
The first injection of this regimen (5000 IU) is started two hours before surgery and the treatment is continued for 7 days.