Adult & childn >12 yr 1-2 vial once daily, may be increased to 4 vial once daily for severe infection. Daily doses >4 vials should be given 12 hrly. Childn <12 yr 20-80 mg/kg/day depending on severity of disease, may be given 24 hrly. Childn >50 kg Adult dose. Treatment of meningitis in infant & childn Initially 100 mg/kg once daily. Pre-op infection prophylaxisAdult 1-2 vials as a single dose 30-90 min pre-op.
Contraindications
Hypersensitivity to cephalosporins & penicillins.
Special Precautions
May cause pseudomembranous colitis in patients who suffer diarrhea after being treated by antibacterial agents; bilirubinemia. Pregnancy & lactation. Neonates (especially premature infants).
Adverse Reactions
Systemic: GI discomfort, diarrhea, nausea, vomiting, stomatitis, glossitis; exanthema, allergic dermatitis, pruritus, urticaria, edema, erythema multiforme; eosinophilia, hematoma, thrombocytopenia, leucopenia, granulocytopenia, haemolytic anemia. Local: Inflammatory reactions in blood vessels after IV administration.
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