Glutalan Dosage/Direction for Use

GLUTALAN is designed for intravenous infusion following additional to a compatible carrier solution. Dosage depends on the severity of the catabolic state and or amino acids requirement. A maximum daily dosage of 2 g amino acids/kg body weight should not be exceeded in parenteral nutrition. The supply of alanine and glutamine via GLUTALAN should be taken into consideration in the calculation. The proportion of the amino acids supplied through GLUTALAN should not exceed approximately 20% of the total supply.
Daily dose: 1.5-2.0 mL of GLUTALAN per kg body weight (equivalent to 0.3-0.4 g L-Alanyl-L-Glutamine per kg body weight).
This equate to 100 to 140 mL GLUTALAN for a patient of 70 kg body weight.
Maximum daily dose: 2.0 mL GLUTALAN per kg body weight. The following adjustments thus result for the amino acids supply through the carrier solution: Amino acids requirement 1.5 g/kg body weight per day: 1.2 g amino acids + 0.3 g L-Alanyl-L-Glutamine per kg body weight.
Amino acids requirement 2 g/kg body weight per day: 1.6 g amino acids + 0.4 g L-Alanyl-L-Glutamine per kg body weight.
The rate of infusion depends on that of the carrier solution and should not exceed 0.1 g amino acids/kg body weight per hour.
GLUTALAN is an infusion solution concentrate which is not designed for direct administration.
It should be mixed with a compatible amino acid carrier solution or and amino acid containing infusion regimen prior to administration. One volume part GLUTALAN is to be mixed with at least 5 volume part carrier solution (e.g. 100 mL GLUTALAN + at least 500 mL amino acid solution).
The maximum infusion concentration should not exceed 3.5%.
The duration of use should not exceed 3 weeks.