Adult: Monotherapy or adjunctive treatment for the symptomatic relief of mild to moderate cases: As glucosamine hydrochloride tab/effervescent tab/cap: Usual dose: 1,250 mg once daily, as a single dose or in 2 divided doses. As glucosamine sulfate tab/powder for oral solution: Usual dose: 1,500 mg once daily, as a single dose or in 2-3 divided doses. Re-evaluate treatment if relief of symptoms is not achieved after 2-3 months.
Administration
Should be taken with food. Preferably taken at meals.
Reconstitution
Effervescent tab: Dissolve in at least 100 mL of water. Powder for oral solution: Dissolve in at least 250 mL of water.
Contraindications
Hypersensitivity to glucosamine and shellfish. Children.
Special Precautions
Patient with impaired glucose tolerance, diabetes mellitus, asthma; known risk factors for CV disease. Rule out the presence of other joint diseases. Not indicated for the treatment of acute painful symptoms. Renal and hepatic impairment. Pregnancy and lactation.
This drug may cause dizziness or drowsiness, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor blood glucose levels prior to and periodically thereafter (in patients with impaired glucose tolerance); cholesterol levels (in at risk for CV disease).
May increase the anticoagulant effects of warfarin and acenocoumarol. May increase the absorption and serum levels of tetracyclines.
Action
Description: Mechanism of Action: Glucosamine is a natural substance found in mucoproteins, chitin, and mucopolysaccharides. It stimulates the synthesis of glycosaminoglycans which are responsible for the formation of cartilage in the body. It may be used as a health supplement in the management of musculoskeletal and joint disorders for its supposed chondroprotective activity. Pharmacokinetics: Distribution: Volume of distribution: Approx 2.5-5 L. Metabolism: Extensively metabolised in the liver. Excretion: Via urine.
Chemical Structure
Storage
Store below 30°C. Protect from light and moisture.