Adult & childn >12 yr 2-6 g daily. Max: 12 g daily. Mild to moderate or uncomplicated infections 1 g 12 hrly. Moderate to severe infections 1 g 8 hrly. Life-threatening infections 2 g 8 hrly. Gonorrhea 1 g IM/IV as a single dose. Childn & infant 1 mth-12 yr 50-180 mg/kg IM/IV in 4-6 equally divided doses. Childn ≥50 kg Adult dose. Max: 12 g daily. Neonate & premature infant 1-4 wk 50 mg/kg 8 hrly; 0-1 wk 50 mg/kg IV 12 hrly. Prophylaxis of post-op infections 1 g IM/IV as a single dose 30-90 min pre-op. Caesarian section 1st dose: 1 g IV immediately after umbilical cord is clamped; 2nd dose: 1 g IV/IM 6 hr after 1st dose; 3rd dose: 1 g IV/IM 12 hr after 1st dose.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
May cause cross-sensitivity reactions in patients w/ hypersensitivity to penicillin. History of GI disease especially colitis. Blood count should be performed in prolonged treatment (>10 days). Renal impairment. Pregnancy & lactation.
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