As monotherapy or in combination w/ sulfonylurea in patients w/ NIDDM & over wt if blood glucose cannot be controlled by diet alone. Adjuvant therapy in hardly controlled IDDM.
Adult Initially 850 mg twice daily or 500 mg 3 times daily, may be increased to max of 3 g daily. Combination w/ sulfonylurea 500 mg or ½ 850 mg caplet daily, may slowly increase the dose until optimal control. May be continued w/ metformin alone. Combination w/ insulin Insulin dosage <60 u daily Initially 500 mg or ½ 850 mg caplet daily while gradually decreasing insulin dosage 4 u every 2-4 day. Dosage may be increased at wkly interval.
View Glikos overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Diabetic coma & ketoacidosis. Chronic liver disease, heart failure & MI, alcoholism, history of lactic acidosis (eg, shock or pulmonary insufficiency & conditions related to hypoxemia). Severe kidney dysfunction. Pregnancy & lactation.
Patient w/ dehydration or recovering from serious infections or trauma. Periodically check vit B12 levels on long-term use; monitor blood sugar levels. Clinically monitor patient for stabilization if treatment is combined w/ insulin. Renal impairment. Childn. Elderly w/ renal impairment.
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