Adult NSCLC In combination w/ cisplatin: Regimen 1 (3-wk schedule): 1,250 mg/m
2 as 30-min IV infusion on days 1, 8 of each 21-day cycle + 75-100 mg/m
2 cisplatin after gemcitabine administration on day 1. Regimen 2 (4-wk schedule): 1,000 mg/m
2 as 30-min IV infusion on days 1, 8, & 15 of each 28-day cycle + 75-100 mg/m
2 cisplatin after gemcitabine administration on day 1. Monotherapy: 1,000 mg/m
2 as 30-min IV infusion, repeated once wkly for 3 wk, followed by 1 wk rest period; repeat 4-wk cycle.
Pancreatic cancer 1,000 mg/m
2 as 30-min IV infusion, repeated once wkly for up to 7 wk, followed by a wk of rest. Subsequent cycles should consist of inj once wkly for 3 consecutive wk out of every 4 wk.
Bladder cancer In combination w/ cisplatin: 1,000 mg/m
2 as 30-min infusion on days 1, 8 & 15 of each 28-day cycle + 70 mg/m
2 cisplatin on day 1 following gemcitabine or day 2 of each 28-day cycle; repeat 4-wk cycle.
Breast cancer In combination w/ paclitaxel: 175 mg/m
2 paclitaxel as IV infusion approx 3 hr on day 1 followed by 1,250 mg/m
2 gemcitabine as 30-min IV infusion on days 1 & 8 of each 21-day cycle.
Ovarian cancer Monotherapy: 800-1,250 mg/m
2 as 30-min IV infusion on days 1, 8 & 15 of each 28-day cycle; repeat 4-wk cycle. In combination w/ carboplatin: 1,000 mg/m
2 as 30-min IV infusion on days 1 & 8 of each 21-day cycle + carboplatin on day 1 consistent w/ a target AUC of 4 mg/mL·min.