Hypersensitivity. History of tendon disease/disorder assoc w/ quinolones; congenital or documented acquired QT prolongation; electrolyte disturbances eg, hypokalaemia; bradycardia; heart failure w/ reduced left-ventricular ejection fraction; symptomatic arrythmias. Concurrent use w/ class IA (eg, quinidine, procainamide) & class III antiarrythmics (eg, amiodarone, sotalol). Patient w/ liver function impairment (Child Pugh C); transaminases increase >5 fold ULN; CrCl <30 mL/min/1.73 m2 (serum creatinine >265 μmol/L) or undergoing renal dialysis. Pregnancy & lactation. Patient <18 yr.
Special Precautions
Hypersensitivity reactions. Patient w/ CNS disorder or history of seizure, visual impairment, myasthenia gravis, complicated pelvic disease. Concomitant medication that reduce K & Mg levels may cause Qtc prolongation. Tendon inflammation & rupture w/ corticosteroids. Discontinue treatment & perform ECG for signs of cardiac arrhythmia. Avoid exposure to UV irradiation or extensive sunlight. Liver dysfunction, pseudomembranous colitis, G6PD deficiencies, SJS, TEN. May impair ability to drive & use machines. Elderly.
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