Gabaxa Dosage/Direction for Use

Gabaxa is designed for intravenous infusion following additional to a compatible carrier solution. Dosage Gabaxa depends of the severity of the catabolic state and or amino acid patient requirements.
A maximum daily dosage of 2 g amino acids/kg body weight should not be exceeded in parenteral nutrition. The supply of alanine and glutamine via Gabaxa should be taken into consideration in the calculation; the proportion of the amino acid supplied through Gabaxa should not exceed approx. 20% of the total supply.
Daily Dose: 1.5-2.0 ml Gabaxa per kg body weight (equivalent to 3.0-0.4 g N(2)-L-Alanyl-L-Glutamine per kg body weight), equivalent with 100-140 ml Gabaxa for a patient of 70 kg body weight.
Maximum daily dose: 2.0 ml Gabaxa per kg body weight.
The following adjustments thus result for the amino acids supply through the carrier solution: Amino acid requirement 1.5 g/kg body weight per day: 1.2 g amino acid + 0.3 g N(2)-L-Alanyl-L-Glutamine per kg body weight.
Amino acid requirement 2 g/kg body weight per day: 1.6 Amino acid + 0.4 g N(2)-L-Alanyl-L-Glutamine per kg body weight.
The rate of infusion depends on that of the carrier solution and should not exceed 0.1 gram Amino acid/kg body weight per hour.
Gabaxa is an infusion solution concentrate which is not designed for direct administration.
Gabaxa should be mixed with a compatible Amino acid carrier solution or an Amino acid containing infusion regiment prior to administration. One volume part Gabaxa is to be mixed with at least 5 volume part carrier solution (e,g. 100 ml Gabaxa + at least 500 ml Amino acid solution). The maximum concentration should not exceed 3.5%.
The duration of use should not exceed 3 weeks.