Farpresin Dosage/Direction for Use

Farpresin may be administered subcutaneous, intramuscularly, intravenously or intraarterially, intranasal use, especially for the treatment of diabetes insipidus has been reported. Ten units of Farpresin (0.5 mL) will usually elicit full physiologic response in adult patients; 5 units will be adequate in many cases. Farpresin should be given intramuscularly at 3- or 4-hour intervals as needed. The dosage should be proportionately reduced for pediatric patients. (For an additional discussion of dosage, consult the sections as follows). When determining the dose of Farpresin for a given case, the following should be kept in mind. It is particularly desirable to give a dose not much larger than is just sufficient to elicit the desired physiologic response. Excessive doses may cause undesirable side effects-blanching of the skin, abdominal cramps, nausea-which, though not serious, may be alarming to the patient. Spontaneous recovery from such side effects occurs in a few minutes. it has been found that one or two glasses of water given at the time Farpresin is administered reduce such symptoms.
Abdominal Distention: In the average postoperative adult patient, give 5 units (0.25 mL) initially; increase to 10 units (0.5 mL) at subsequent injections if necessary. lt is recommended that Farpresin be given intramuscularly and that injections be repeated at 3- or 4-hour intervals as required. Dosage to be reduced proportionately for pediatric patients. Farpresin used in this manner will frequently prevent or relieve postoperative distention. These recommendations apply also to distention complicating pneumonia or other acute toxemias.
Abdominal Roentgenography: For the average case, two injections of 10 units each (0.5 mL) are suggested. These should be given two hours and one-half hour, respectiveiy, before films are exposed. Many roentgenologists advise giving an enema prior to the first dose of Farpresin.
Diabetes Insipidus: Farpresin may be given by injection or administered intranasally on cotton pledgets, by nasal spray, or by dropper. The dose by injection is 5 to 10 units (0.25 to 0.5 mL) repeated two or three times daily as needed. When Farpresin is administered intranasally by spray or on pledgets, the dosage and interval between treatments must be determined for each patient.
EMERGENCY MANAGEMENT OF ACUTE UPPER GASTROINTESTINAL BLEEDING: Has been administered by continuous intravenous infusion and by selective infusion via superior or inferior mesenteric artery. Because the intravenous route is relatively more convenient and accessible, it is generally recommended as the first choice.
A range dose regimens has been found to be effective. By the intravenous route, infusion with a concentration of 0.2 to 0.6 U/min. The initial infusion rate is then increased at 30 to 60 minute interval to 0.6 U/min or more if the bleeding is not controlled and the patient is tolerating the infusion. After bleeding is controlled, continue effective dose for 12 to 24 hours. Dose should then be gradually tapered over the next 24 to 48 hours.