Exocid

Esomeprazole Na

Gastric antisecretory when oral route is not possible eg, GERD in patients w/ esophagitis &/or severe symptoms of reflux, healing of gastric ulcer associated w/ NSAID therapy. Short-term maintenance of hemostasis & prevention of rebleeding in patients following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers.

Gastric antisecretory 20-40 mg IV once daily. Reflux esophagitis 40 mg once daily. Symptomatic treatment for reflux disease 20 mg once daily. Healing of gastric ulcer associated w/ NSAID therapy 20 mg once daily. Short-term maintenance of hemostasis & prevention of rebleeding of gastric & duodenal ulcers 80 mg bolus infusion over 30 min, followed by continuous IV infusion of 8 mg/hr given over 3 days (72 hr).

Hypersensitivity. Concomitant use w/ atazanavir & nelfinavir.

Exclude gastric malignancy before treatment. Pregnancy & lactation.

Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypersensitivity reactions, peripheral oedema, hyponatremia, insomnia, agitation, confusion, depression, aggressiveness, hallucination, headache, dizziness, paraesthesia, somnolence, taste disturbances, blurred vision, vertigo, bronchospasm, abdominal pain, constipation, diarrhea, flatulence, nausea/vomiting, dry mouth, stomatitis, GI candidiasis, increased liver enzyme, hepatitis (w/ or w/o jaundice), liver damage, encephalopathy in patients w/ liver disease, local reactions at inj site, dermatitis, pruritus, skin redness, urticaria, alopecia, photosensitivity, erythema multiforme, SJS, TEN, arthralgia, myalgia, muscle weakness.

Ketoconazole, diazepam, citalopram, phenytoin, warfarin, other coumarin derivatives, cisapride, atazanavir, nelfinavir, saquinavir, voriconazole.

Antacids, Antireflux Agents & Antiulcerants

A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

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