Eterfix

Paracetamol

Short term treatment of moderate pain (especially after surgery) & short term treatment of fever. When administration by IV route is clinically justified by an urgent need to treat pain & hyperthermia &/or when other route of administration are not possible.

Childn weighing >10 kg & <33 kg 15 mg/kg, interval 6 hr. Neonate, childn weighing ≤10 kg 7.5 mg/kg, interval 6 hr.

Hypersensitivity to paracetamol or to propacetamol HCl (prodrug of paracetamol). Severe hepatocellular insufficiency. Patients w/ hepatic failure or active liver disease.

Chronic alcoholism. Chronic malnutrition (low reserves of hepatic gluthatione). Dehydration. Hepatocellular insufficiency, severe renal insufficiency (CrCl ≤30 mL/min).

Skin rash or urticaria. Hypersensitivity reaction. Malaise. Hypotension. Increased transaminase serum level in liver. Thrombocytopenia, leukopenia, neutropenia.

Decrease dosage of paracetamol if taken for a prolonged period of time w/ anticoagulant drugs eg, warfarin. Increased absorption w/ substances that increase gastric emptying eg, metoclopramide. Decreased absorption w/ substances that decrease gastric emptying eg, propantheline, antidepressants w/ anticholinergic properties & narcotic analgesics. May increase chloramphenicol conc. Risk of paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes eg, alcohol & anticonvulsant agents. Paracetamol excretion may be affected & plasma conc altered when given w/ probenecid. Colestyramine reduces the absorption of paracetamol if given w/in 1 hr of paracetamol.

Analgesics (Non-Opioid) & Antipyretics

N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.

G