As other corticosteroids, Clobetasol propionate has topical anti inflammatory characteristics. Corticosteroids act through the induction of phospholipase A2 inhibitor proteins, collectively known as lipocortine. It is postulated that these proteins modulate the biosynthesis of inflammatory mediators, e.g. prostaglandins and leucotrienes, by inhibiting their precursor (i.e Arachidonic acid) release. Arachidonic acid is released from phospholipids membrane by phospholipase A2.
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