Duloxta Dosage & Drug Information

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Concise Prescribing Info

Contents

Duloxetine

Indications/Uses

Depression. Diabetic peripheral neuropathic pain (DPNP). Treatment of generalized anxiety disorder (GAD) & prevention of recurrence for 6 mth.

Dosage/Direction for Use

Depression & DPNP Initially 60 mg once daily. Max: 120 mg daily in 2 divided doses. GAD Initially 30 mg once daily, may increase to 60 mg if insufficient response.

Administration

May be taken with or without food.

Contraindications

Concomitant use w/ non-selective irreversible MAOIs & potent CYP1A2 inhibitors eg, fluvoxamine, ciprofloxacin, enoxacin. Hepatic & severe renal (CrCl <30 mL/min) impairment.

Special Precautions

Suicidal tendency in bipolar depression. Activation of mania/hypomania. Seizure, mydriasis. Substantial alcohol use. Monitor BP. Rare heredity problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose insufficiency. May impair ability to drive & operate machinery. Renal or hepatic impairment. Pregnancy & lactation. Monitor in childn & adolescents <18 yr.

Adverse Reactions

Nausea, headache, dry mouth, fatigue, somnolence, insomnia, dizziness, constipation, diarrhea, decreased appetite, hyperhydrosis.

View ADR Monitoring Form

Drug Interactions

Drugs metabolised by & inhibitors of CYP1A2 & CYP2D6. CNS drugs. SSRIs, serotonin & norepinephrine reuptake inhibitors, triptans, tramadol, highly protein-bound drugs, steroids, MAOIs.

MIMS Class

Antidepressants / Drugs for Neuropathic Pain

ATC Classification

N06AX21 - duloxetine ; Belongs to the class of other antidepressants.

Presentation/Packing

Form

Duloxta DR cap 60 mg

Packing/Price

2 × 10's (Rp250,000/boks)

Duloxta

duloxetine

Manufacturer:

Mersifarma TM