Cyclophosan Dosage/Direction for Use

Dosage: The dosage regimen should be tolerated to the individual requirements of the patient, depending on his general condition, concurrent therapy, the type and state of tumour, and the patient's response.
Three sample regimens may serve as guides: Low dose: 80 to 240 mg/m² body surface (2 to 6 mg/kg body weight), as a single dose weekly i.v. or in divided doses orally.
Medium dose: 400 to 600 mg/m² body surface (10 to 15 mg/kg body weight), as a single dose weekly i.v.
High dose: 800 to 1,600 mg/m² body surface (20 to 40 mg/kg body weight), as a single dose i.v. at 10-20 day intervals.
Higher doses should be used only at the discretion of a physician experienced in cytotoxic chemotherapy.
Direction for Use: Reconstitute with 10 mL sterile water for injection for 200 mg of Cyclophosphamide. Shake vigorously. Do not warm.
Concentration after Reconstitution: Each mL contains 21.4 mg Cyclophosphamide Monohydrate equivalent to 20 mg Cyclophosphamide Anhydrous.