Burosumab is used to treat a genetic disease or a rare disorder that causes a low level of phosphorus in the blood.
Low level of phosphorus can lead to pain and stiffness in bones and joints, and it may also affect bone growth in children and adolescents.
Burosumab is to be injected subcutaneously (into the fatty layer under the skin, usually in the thigh, upper arm or abdomen area).
Your doctor or nurse will administer the injection for you.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type of your disease.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Burosumab.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
Alert your doctor if you have the following conditions:
- phosphorus level in the blood that is within or above the normal range for your age
- severe kidney disease
as Burosumab may not be suitable for you.
Do not use this medicine with any phosphate supplements or other supplements that contain active vitamin D.
Let your doctor know if you are pregnant or breastfeeding.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine tests (e.g. phosphorus levels in the blood, parathyroid hormone, calcium and phosphate level in the urine) may be done while you are being treated with Burosumab. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring of signs and symptoms of increased calcium level in the kidneys (such as blood in the urine), allergic or injection site reactions may also be needed.
Burosumab may cause any of the following side effects: headache, dizziness, back pain, muscle pain or spasm, pain in hands and feet, tooth abscess, toothache, constipation, fever, diarrhoea, vomiting, nausea, cough, pain, itching, or redness at the injection site, and irresistible urge to move the legs to stop uncomfortable or odd sensations in the legs.
If you develop rashes, breathlessness, swollen mouth or eyes, inform your doctor immediately. These could be signs of an allergic reaction.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not use Burosumab with the following medicines:
- phosphate supplements
- vitamin D supplements e.g. calcitriol, calcifediol, doxecalciferol, paricalcitol
Inform your doctor and pharmacist if you are taking calcimimetics (medicines that work in the same way as calcium in the body).
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in the refrigerator, between 2-8°C.
Do not freeze Burosumab otherwise, it will no longer be effective and should not be used.
Protect from light.
Medicines must not be used past the expiry date.
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