Bevacizumab is used together with other medicines to treat cancer of the colon, breast, kidney, lungs, brain, ovary, and cervix.
Bevacizumab injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.
Your doctor or nurse will administer the injection for you.
Ensure that you keep all appointments with your doctor so that you do not miss any dose.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
Do not use Bevacizumab if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. This medicine may cause harm to your unborn child. You must use proven birth control methods during treatment and up to 6 months after you stop taking this medicine.
Do not breastfeed while you are being treated with this medicine and up to 6 months after treatment.
Inform your doctor if you have the following conditions:
- cancer cells that have spread to other parts of the body
- kidney disease
- heart disease
- high blood pressure
- stomach ulcer
- bleeding problems
If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may need to do routine laboratory tests (e.g. complete blood count, urine protein levels) while you are being treated with this medicine. Your blood pressure should also be monitored during treatment and after discontinuation of your treatment.
Bevacizumab may cause sleepiness and fainting. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, tiredness, weakness, anxiety, weight loss, stomach pain, nausea, vomiting, indigestion, diarrhoea, constipation, loss of appetite, changes in taste, dry mouth, muscle pain, back pain, pelvic pain, dry or flaky skin, hair loss, hand-foot syndrome (redness, swelling, and pain of the palms of hand and/or soles of the feet), voice changes, numbness and tingling in your hands or feet, nosebleed, stuffy or runny nose and pain, swelling, and redness at the injection site.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- fever with persistent sore throat or mouth ulcers, unusual bleeding or bruising
- pain and swelling in your arms and legs
- shortness of breath and chest pain
- pass out blood or black, tarry stools or vomit coffee-ground-like vomitus
- discharge of blood when having bowel movement
- foul-smelling vaginal discharge, irritation and pain between your vagina and anus
- wound that does not heal
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- other medicines for cancer e.g. sunitinib, irinotecan, epirubicin, capecitabine
- medicines for mood disorders e.g. clozapine
This list does not include all medicines that may interact with Bevacizumab.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a refrigerator (2°C-8°C). Do not freeze.
Keep the vial in the outer carton in order to protect from light.
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