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Pharmacology: Cream: Mechanism of Drug Action: Mupirocin is produced by fermentation using the organism Pseudomonas fluorencens. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer RNA synthetase. Due to this mode of action, Mupirocin demonstrates no in vitro cross-resistance with fusidic acid, chloramphenicol, erythromycin, gentamicin, lincomycin, methicillin, neomycin, novabiocin, penicillin, streptomycin and tetracycline.
Ointment: Mupirocin is a topical antibacterial agent, active against those organisms responsible for the majority of skin infections e.g. Staphylococcus aureus, including methicillin-resistant strains, other staphylococci, and streptococci. It is also active against Gram-negative organisms such as Escherichia coli and Haemophilus influenzae.
Pharmacokinetics: Absorption and Excretion: BACTODERM ointment penetrates into human skin but the rate of systemic penetration appears to be low. Systemically absorbed, BACTODERM is rapidly metabolized to the inactive metabolite, monic acid, and quickly excreted by the kidneys.
