Alclometasone


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% cream/oint: Apply sparingly a thin film onto the affected area 2-3 times daily, for up to 7 days. Longer duration of treatment w/ appropriate monitoring may be necessary in patients w/ resistant or chronic conditions.
Child: ≥1 yr Same as adult dose. Do not use for >3 wk.
Contraindications
Broken skin, tuberculous or viral (e.g. herpes simplex, vaccinia, varicella) skin lesions, fungal (e.g. candidiasis, tinea) or bacterial (e.g. impetigo) skin infections, rosacea, acne, perioral dermatitis.
Special Precautions
Patient w/ seborrhoeic dermatitis, psoriasis. Childn. Pregnancy and lactation.
Adverse Reactions
Itching, burning, erythema, dryness, irritation, papular rashes; folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, miliaria, and maceration. Rarely, adrenal suppression, Cushing’s syndrome.
Patient Counseling Information
Do not apply on the face, eyes, underarm, groin, breast-fold, genitals, or between the toes.
Monitoring Parameters
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test, and urinary free cortisol test.
Overdosage
Symptom: Adrenal insufficiency/hypercorticism (e.g. Cushing’s disease). Management: Symptomatic and supportive treatment. Treat electrolyte imbalance if necessary.
Action
Description:
Mechanism of Action: Alclometasone, a synthetic glucocorticoid, induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the biosynthesis and activity of prostaglandins, leukotrienes, and other inflammatory mediators.
Pharmacokinetics:
Absorption: Approx 3% is absorbed systemically after 8 hr when applied to intact skin.
Metabolism: Extensively metabolised into polar, unidentified metabolites.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image
Alclometasone

Source: National Center for Biotechnology Information. PubChem Database. Alclometasone, CID=5311000, https://pubchem.ncbi.nlm.nih.gov/compound/Alclometasone (accessed on Jan. 20, 2020)

Storage
Store between 2-30°C.
MIMS Class
Topical Corticosteroids
ATC Classification
D07AB10 - alclometasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
References
Alclometasone Dipropionate Ointment. DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 09/08/2016.

Anon. Alclometasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/08/2016.

Buckingham R (ed). Alclometasone Dipropionate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016.

Joint Formulary Committee. Alclometasone Dipropionate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Alclometasone Dipropionate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 09/08/2016.

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