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Zadaxin日達仙

Zadaxin

thymalfasin

Manufacturer:

SciClone

Distributor:

Firma Chun Cheong
/
Jacobson Medical
Concise Prescribing Info
Contents
Thymosin α-1 (Thymalfasin)
Indications/Uses
Treatment of chronic hepatitis B in patients w/ compensated hepatic disease & HBV replication. Adjuvant (immune response enhancer) for flu vaccination in immunocompromised &/or elderly patients. Adjuvant for both flu & hepatitis B vaccines in chronic haemodialysis patient who failed to achieve adequate antibody titres from previous immunisation.
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Dosage/Direction for Use
SC inj only. Chronic hepatitis B 1.6 mg twice wkly w/ 3-4 days interval for 6 mth (52 doses) w/o interruption. Vaccine adjuvant 900 mcg/m2 (1.6 mg) twice wkly w/ 3-4 days interval & 1st dose given coincident w/ vaccine. Continue for 4 wk (total: 8 doses) after a single-dose vaccine immunisation regimen. For multidose vaccine immunisation regimen, continue twice wkly between vaccinations & for 3 wk (total: 5-6 doses) after last vaccination.
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Overdosage
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Contraindications
Immunosuppressed eg, transplant patient.
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Special Precautions
Pregnancy & lactation.
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Adverse Reactions
Local discomfort at inj site. Rarely, erythema, transient muscle atrophy, polyarthralgia w/ hand oedema, rash.
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Drug Interactions
Other immunomodulators.
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Storage
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Description
View Zadaxin description for details of the chemical structure and excipients (inactive components).
Action
View Zadaxin mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Vaccines, Antisera & Immunologicals / Antivirals
ATC Classification
L03AX - Other immunostimulants ; Used as immunostimulants.
Presentation/Packing
Form
Zadaxin powd for inj 1.6 mg
Packing/Price
(vial + 1 mL diluent (amp)) 2 × 1's ($1,700/box)
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