Bone marrow suppression. Perform haematological evaluation at baseline & prior to every dose. Use w/ caution in patients w/ evidence of compromised bone marrow reserve. Monitor patients' oral intake & fluid status & promptly treat patients who display signs or symptoms of dehydration or hypovolemia. May be associated w/ increased risk of cancer & hereditary effects. Not recommended for use in combination w/ abiraterone acetate + prednisone/prednisolone, or other chemotherapy. Potential effects on spermatogenesis associated w/ radiation. Potential risk of impaired human fertility. Can cause fetal harm. Use effective contraceptive methods during & up to 6 mth after treatment. Not indicated for use in women.
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