Higher frequency of adverse events w/ ACE inhibitors or aliskiren. Potential interaction w/ diuretics; lithium; K-sparing diuretics, K supplements, salt substitutes containing K & other substances that may increase K levels; NSAIDs or COX-2 inhibitors; anticonvulsants (eg, carbamazepine, phenobarb, phenytoin, fosphenytoin, primidone); St. John's wort; nitroglycerin & other nitrates, or other vasodilators; medicines for HIV/AIDS (eg, ritonavir, indinavir, nelfinavir); antifungals (eg, ketoconazole, itraconazole); antibiotics eg, rifampicin, erythromycin, clarithromycin, talithromycin; verapamil, diltiazem; simvastatin; dantrolene; ciclosporin, tacrolimus. Increased blood levels of amlodipine w/ grapefruit/grapefruit juice.
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