May cause changes to pigmented tissues (eg, increased pigmentation of the iris & periorbital tissue). May gradually change eyelashes & vellus hair in the treated eye (including increased length, thickness & the number of lashes or hairs). Caution in patients w/ history of intraocular inflammation (iritis/uveitis) & should generally not be used in patients w/ active intraocular inflammation. Reports of macular edema, including cystoid macular edema; caution in aphakic patients, in pseudophakic patients w/ a torn posterior lens capsule, or in patients w/ known risk factors for macular edema. Remove contact lenses prior to administration. Pregnancy & lactation. Not recommended in ped patients ≤16 yr.
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