Vyepti Dosage/Direction for Use

The treatment should be initiated by a healthcare professional experienced in the diagnosis and treatment of migraine. The infusion of VYEPTI should be initiated and supervised by a healthcare professional.
Posology: The recommended dose is 100 mg administered by intravenous infusion every 12 weeks. Some patients may benefit from a dosage of 300 mg administered by intravenous infusion every 12 weeks (see Pharmacology: Pharmacodynamics under Actions).
The need for dose escalation should be assessed within 12 weeks after initiation of the treatment. When switching dosage, the first dose of the new regimen should be given on the next scheduled dosing date.
Overall benefit and continuation of treatment should be assessed 6 months after initiation of the treatment. Any further decision to continue the treatment should be made on an individual patient basis.
Special Populations: Elderly (aged 65 years and over): There is limited data available for the use of VYEPTI in patients ≥65 years of age. No dose adjustment is required in the elderly patients as the pharmacokinetics of eptinezumab were not affected by age.
Renal impairment/hepatic impairment: No dose adjustment is required in patients with renal impairment or hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).
Paediatric population: The safety and efficacy of VYEPTI in children aged 6 to 18 years has not yet been established. Currently no data are available.
There is no relevant use of VYEPTI in children below the age of 6 years for the prophylaxis of migraine.
Method of administration: VYEPTI is for intravenous use only after dilution.
For instructions on dilution of the medicinal product prior to administration, see Special precautions for disposal and other handling under Cautions for Usage.
Following dilution, infuse VYEPTI, over approximately 30 minutes.
The treating healthcare professional should observe or monitor patients during and after the infusion in accordance with normal clinical practice.
Do not administer VYEPTI as a bolus injection.