Co-administration of Viread w/ drugs that are eliminated by active tubular secretion may increase conc of tenofovir &/or the co-administered drug [eg, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (eg, gentamicin), & high-dose or multiple NSAIDs]. In chronic hepatitis B treatment, do not administer w/ adefovir dipivoxil. Increased conc of didanosine. Increased tenofovir conc w/ drugs that decrease renal function; lopinavir/ritonavir, atazanavir/ritonavir, darunavir/ritonavir; sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, ledipasvir/sofosbuvir.