Adult, adolescent & childn ≥50 kg Monotherapy 50 mg bd. Increase to initial therapeutic dose of 100 mg bd after 1 wk. Can also be initiated at 100 mg bd. Maintenance dose: Can be further increased at wkly intervals by 50 mg bd. Max: 300 mg bd.
Adjunctive therapy 50 mg bd. Increase to 100 mg bd after 1 wk. Maintenance dose: Can be further increased at wkly intervals by 50 mg bd. Max: 200 mg bd.
Loading dose Treatment may also be initiated w/ 200 mg single loading dose, followed approx 12 hr later by 100 mg bd (200 mg/day) maintenance dose.
Mild or moderate renal impairment No dose adjustment necessary. 200 mg loading dose may be considered, but perform further dose titration (>200 mg daily) w/ caution.
Severe renal impairment or end-stage renal disease Max: 250 mg/day. Perform dose titration w/ caution.
Mild to moderate hepatic impairment Max: 300 mg/day.
Childn ≥4 yr & adolescent <50 kg Dose is determined based on body wt.
Monotherapy 2 mg/kg/day. Increase to initial therapeutic dose of 4 mg/kg/day after 1 wk. Maintenance dose: Can be further increased by 2 mg/kg/day every wk. Max in childn 40 to <50 kg: 10 mg/kg/day. Max dose in childn <40 kg: 12 mg/kg/day.
Adjunctive therapy 2 mg/kg/day. Increase to initial therapeutic dose of 4 mg/kg/day after 1 wk. Maintenance dose: Can be further increased by 2 mg/kg/day every wk. Max in childn 30 to <50 kg: 8 mg/kg/day. Max in childn 20 to <30 kg: 10 mg/kg/day. Max dose in childn <20 kg: 12 mg/kg/day.
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