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Posology: Based on clinical experience with the trivalent vaccine, annual revaccination with influenza vaccine is recommended given the duration of immunity provided by the vaccine and because circulating strains of influenza virus might change from year to year.
Adults: one dose of 0.5 ml.
Paediatric population: Children from 6 months to 17 years of age: one dose of 0.5 ml.
For children less than 9 years of age who have not previously been vaccinated, a second dose of 0.5 ml should be given after an interval of at least 4 weeks.
Infants less than 6 months of age: the safety and efficacy of Quadrivalent Influenza Vaccine (split virion, inactivated) administration (active immunisation) have not been established. No data are available.
Regarding passive protection: one 0.5ml dose given to pregnant women may protect infants from birth to less than 6 months of age; however, not all these infants will be protected (see Pharmacology: Pharmacodynamics under Actions).
Method of administration: The vaccine should be given by intramuscular or subcutaneous injection.
The preferred sites for intramuscular injection are the anterolateral aspect of the thigh (or the deltoid muscle if muscle mass is adequate) in children 6 months through 35 months of age, or the deltoid muscle in children from 36 months of age and adults.
Precautions to be taken before handling or administering the medicinal product: For instructions on preparation of the medicinal product before administration, see Special precautions for disposal and other handling under Cautions for Usage.
