Patients w/ hyperkalemia or conditions predisposing to hyperkalemia (eg, chronic renal failure, uncontrolled DM, acute dehydration, strenuous physical exercise in unconditioned individuals, adrenal insufficiency, extensive tissue breakdown or administration of a K-sparing agent); patients in whom there is cause for arrest or delay in tab passage through the GI tract eg, delayed gastric emptying, esophageal compression, intestinal obstruction or stricture, or those taking anticholinergic medication; patients w/ peptic ulcer disease; active UTI (w/ either urea-splitting or other organisms, in association w/ either Ca or struvite stones); renal insufficiency (GFR <0.7 mL/kg/min).